The group are being questioned by police on suspicion of breaking into homes and garages.
They were arrested in a raid in Worthing town centre by officers investigating a series of burglaries and attempted burglaries in Goring.
When the males aged 26, 25, 18 and 17 and a 22-year-old woman were arrested, a large number of items suspected of having being stolen in break-ins were discovered and seized.
The five, who are all from Worthing, are being questioned on suspicion of breaking into a house and a garage in Rose Walk, Goring, late on Sunday 18 August or early on Monday 19 August.
Between 11pm and 6am a burglar got in through a patio door at a home in the road and took thousands of pounds worth of valuables.
The thief escaped with a red and white Specialised Epic Comp bike, a sat nav system, a pair of Oakley sunglasses, a video camera, a digital camera and a mobile phone as well as bank cards and a driving licence.
A £500 bike was stolen after the garage at a nearby home was broken into at about the same time.
Detective Inspector Andy Westwood, of West Sussex CID, said: “I would urge anyone who knows anything about the incidents to contact us with any information they have, no matter how insignificant it might seem to them.
“If you see anyone acting suspiciously in the area dial 999. Don’t wait to see if anyone else is going to call us.
“We need the public’s help to prevent more people becoming victims of burglars and would also warn residents to make sure they help themselves by making their homes secure.”
Anyone with information should call 101 quoting serial 1616 of 19 August or the independent charity Crimestoppers anonymously on 0800 555111.