Brighton have beaten Southampton and Newcastle in their previous two top flight encounters and a first ever victory at Old Trafford would pull Potter's team further away from the relegation places.
In will be no easy task however as United are second in the league standings and three points for Ole Gunnar Solskjaer's team would boost their chances of a top four finish.
Albion will be without defenders Adam Webster and Dan Burn for this one and will hope Jakub Moder and Leo Trossard can continue their fine form.
Scroll down and click through to see our predicted starting XI.
1. Robert Sanchez
Returned from the international break after his first taste of the Spain camp following his call-up to Luis Enrique's squad. Will be keen to impress at Old Trafford and Brighton will need him at his best against a potent United attack
2. Ben White
Likely to be used on the right side of a defensive trio as Brighton continue to adapt their defence due to the absence of Dan Burn and Adam Webster. Could be in for a tough evening up against Rashford - if the Man U striker is declared fit
3. Lewis Dunk
The skipper has simply been Albion's best player this season. Even more vital at the moment with Webster and Burn struggling with fitness. Will love the big occasion at Old Trafford
4. Joel Veltman
The versatile Dutch international defender will likely take his place on the left of the three man defence. What a signing he has proved to be for Brighton