Perhaps surprisingly, the Hammers have failed to beat Brighton in the Premier League, losing three and drawing three of their six previous meetings with the Seagulls in the top flight.
Brighton have also performed better on their travels this season, picking up eight of their 12 points away from the Amex.
West Ham have impressed this season and fans will doubt expect another three points today but Brighton have played some good stuff of their own without getting the points they have deserved.
Scroll down and click through to see how David Moyes' men could line-up for this one
1. Fabianski
The reliable Polish keeper will take his place between the sticks at the London Stadium
2. Vladimír Coufal
The Czech defender is set to feature at right back up against Solly March
3. Fabian Balbuena
The Paraguayan centre back will be up against Brighton's Danny Welbeck
4. Ogbonna
The experienced defender has been a reliable presence for West Ham this season